翻訳と辞書 |
Norethisterone acetate : ウィキペディア英語版 | Norethisterone acetate
Norethisterone acetate (INN, BAN), also known as norethindrone acetate (USAN), sold under brand names including Aygestin, Gestakadin, Milligynon, Monogest, Norlutate (Canada, USA distributed by ERFA Canada 2012 Inc.〔http://www.eci2012.net/〕), Primolut (Fr., Ger., Swed.), Sovel, Styptin, and others, is a steroidal progestin with additional antigonadotropic (and hence antiandrogen and antiestrogen) effects that is used as a hormonal contraceptive. It is an acetate ester of norethisterone.〔(Norethisterone Acetate @ Drugs.com )〕 Norethindrone acetate is indicated for abnormal uterine bleedings.〔http://www.drugs.com/ppa/norethindrone-acetate.html〕 ==Synthesis==
Reaction of norethindrone (1) with acetic anhydride in the presence of ''p''-toluene sulfonic acid, affords norethindrone acetate (2).〔 This in turn affords, on reaction with exess cyclopentanol in the presence of excess phosphorus pentoxide, the 3-cyclopentyl enol ether (3),〔 the progestational component of Riglovic®.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Norethisterone acetate」の詳細全文を読む
スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|