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・ Norene Forbes
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・ Norepinephrine releasing agent
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Norethisterone acetate
・ Norethisterone enanthate
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Norethisterone acetate : ウィキペディア英語版
Norethisterone acetate

Norethisterone acetate (INN, BAN), also known as norethindrone acetate (USAN), sold under brand names including Aygestin, Gestakadin, Milligynon, Monogest, Norlutate (Canada, USA distributed by ERFA Canada 2012 Inc.〔http://www.eci2012.net/〕), Primolut (Fr., Ger., Swed.), Sovel, Styptin, and others, is a steroidal progestin with additional antigonadotropic (and hence antiandrogen and antiestrogen) effects that is used as a hormonal contraceptive. It is an acetate ester of norethisterone.〔(Norethisterone Acetate @ Drugs.com )〕
Norethindrone acetate is indicated for abnormal uterine bleedings.〔http://www.drugs.com/ppa/norethindrone-acetate.html〕
==Synthesis==

Reaction of norethindrone (1) with acetic anhydride in the presence of ''p''-toluene sulfonic acid, affords norethindrone acetate (2).〔 This in turn affords, on reaction with exess cyclopentanol in the presence of excess phosphorus pentoxide, the 3-cyclopentyl enol ether (3),〔 the progestational component of Riglovic®.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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